One vaccine against all variants and the future outbreak of the Corona virus: It does not seem impossible

It has been shown that people infected with SARS produce antibodies after Pfizer vaccination that successfully fight not only known coronavirus variants, but also other worrisome coronaviruses.

Many people agree: We should try to avoid the next pandemic no matter what. However, scientists warn that we may be headed towards it era of epidemics. It is not impossible for new coronaviruses to emerge. Therefore, researchers are seriously looking for a comprehensive vaccine for corona that not only protects against all current circulating corona variants, but also protects against future corona virus outbreaks. Important steps have now been taken in this endeavour.

Various Corona Viruses
In the coronavirus family, one subgroup infects human cells through the ACE2 receptor (a kind of “home key” that allows the virus to enter our cells). Both the SARS-CoV-1 virus that broke out in 2003 and the current circulating coronavirus (SARS-CoV-2) belong to this group, along with a number of other coronaviruses that circulate in animals such as bats, pangolins and civets. Although the exact transmission path is still unknown, we do know that these viruses can pass from animals to humans and cause another pandemic. Collectively, this group is called Sarpicviruses. The broader subgenre.

study
Researchers are searching for a single vaccine that could protect against this whole group study between different people. They collected eight people infected with SARS from among their members in 2003, but have since fully recovered. Ten healthy people as well as ten COVID-19 survivors have also been recruited. Next, the team compared the immune response before and after they were injected with the Pfizer-BioNTech mRNA vaccine.

Specifically, the researchers wanted to understand whether neutralizing antibodies to people who had been infected with SARS could destroy both SARS-CoV-1 and SARS-CoV-2 viruses. And what do they do against the entire family of sarpic viruses, including the potentially zoonotic sarpic viruses that have been detected in bats and pangolins?

It leads to an interesting discovery. Because researchers found that people who had SARS and were vaccinated with Pfizer produced very strong and effective antibodies. These antibodies can neutralize not only the known variants of SARS-CoV-2, but also other animal coronaviruses of concern.

SARS survivors
“Before vaccination, SARS-CoV-1 survivors had detectable neutral antibodies only to SARS-CoV-1, but neither SARS-CoV-2 nor low levels of antibody,” researcher Wanni Chia explains. “But after two doses of the Pfizer vaccine, they all had high levels of neutralizing antibodies to both SARS-CoV-1 and SARS-CoV-2. They are the only group that now has a broad spectrum of neutralizing antibodies that can compete with ten Sarpcoviruses. thoughtful.”

universal vaccine
It is a promising discovery. Because it is the first time such “cross-neutralization activity” has been shown in humans. Therefore, it boosts hope for the development of an effective and comprehensive vaccine that can protect the next generation from various coronaviruses. Wang Linfa concludes: “Our study indicates the development of a vaccine that will not only help us during the current COVID-19 pandemic, but also prevent or reduce the risk of future epidemics caused by related viruses.”

We already see that current vaccines do not provide complete protection against the new, emerging and worrying variants of corona. For example, researchers recently came to the news that Pfizer and AstraZeneca both offer less protection against the increasingly dominant delta variant. Thus, a universal vaccine could offer a solution. “This could address the problem, while at the same time serving as a preventative vaccine against future pandemics caused by the coronavirus,” says researcher David Lai.