Pregnancy after breast cancer in young BRCA carriers

The results of a global study showed that 1 in 5 young people BarcaCarriers became pregnant within 10 years of being diagnosed with breast cancer. Pregnancy after breast cancer in this population was also not associated with reduced disease-free survival.

This retrospective international cohort study examined the cumulative incidence of pregnancy and disease-free survival in women diagnosed with invasive breast cancer at age ≥ 40 years who carry pathogenic germline variants in BRCA1 wow BRCA2. The study population included 4732 BarcaPregnant women diagnosed with breast cancer at 78 participating centers worldwide between January 2000 and December 2020. The last delivery occurred on October 7, 2022, and the last follow-up was on February 20, 2023. The primary endpoints were cumulative incidence of pregnancy after breast cancer and survival Alive and free of disease. Secondary endpoints were breast cancer-specific and overall survival, and fetal and obstetric outcomes.

Out of 4732 participants 659 had at least one pregnancy after breast cancer. The cumulative incidence of pregnancy at 10 years was 22%, with a median time of 3.5 years between breast cancer diagnosis and pregnancy. Of the 659 pregnant patients, 6.9% had an induced abortion and 9.7% had a miscarriage. Of the 517 patients whose pregnancies were completed, 91% delivered at ≥37 weeks and 10.4% delivered twins. Of the 470 children for whom information was available about pregnancy complications, 0.9% of them suffered from congenital malformations. Median follow-up was 7.8 years, with no significant difference in disease-free survival between patients with and without pregnancy after breast cancer (HR 0.99). Patients who became pregnant had significantly better breast cancer and overall survival.

source:

Lambertini M, Blundo E, Agostinito E, et al. Pregnancy after breast cancer in young BRCA carriers: an international hospital-based cohort study. Gamma. 2024;331:49-59.